HLA-G functions as a restriction element and a transplantation antigen in mice.

@article{Horuzsko1997HLAGFA,
  title={HLA-G functions as a restriction element and a transplantation antigen in mice.},
  author={Anatolij Horuzsko and John Antoniou and Peter D. Tomlinson and Vera Portik-Dobos and Andrew L Mellor},
  journal={International immunology},
  year={1997},
  volume={9 5},
  pages={645-53}
}
HLA-G, a human MHC class I molecule expressed on the trophoblast during pregnancy, was expressed in transgenic mice by recombining the HLA-G gene with a transcriptional promoter from a murine H-2 MHC class I gene. Skin grafts from HLA-G transgenic mice were rejected by non-transgenic mice showing that HLA-G behaves as a xenotransplantation antigen in mice. Further investigation revealed that murine T cells recognize native HLA-G directly as a xenoantigen or they recognize processed peptides… CONTINUE READING
11 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…