HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy

  title={HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy},
  author={Vera Rebmann and Fabiola da Silva Nardi and Bettina Wagner and Peter A. Horn},
  booktitle={Journal of immunology research},
HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental… CONTINUE READING

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