HLA-G and CD8+ regulatory T cells in the inflammatory environment of pre-eclampsia.

@article{Vianna2016HLAGAC,
  title={HLA-G and CD8+ regulatory T cells in the inflammatory environment of pre-eclampsia.},
  author={Priscila Vianna and Andressa Grazziotin Mondadori and Mois{\'e}s Evandro Bauer and Dinara Dornfeld and Jos{\'e} Artur Bogo Chies},
  journal={Reproduction},
  year={2016},
  volume={152 6},
  pages={741-751}
}
During pregnancy, the maternal immune system is tolerant to foetal antigens via the engagement of immune regulatory mechanisms. Failure in regulating the maternal immunity to foetal antigens may lead to pre-eclampsia (PE). We addressed the role of HLA-G gene polymorphisms and protein expression as well as regulatory T cells and Th1/Th2/Th17 cytokines in healthy and pathological pregnancies. Blood samples from 26 pregnant women with PE, 25 non-PE and 7 strictly healthy pregnant women were… CONTINUE READING