HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia

@inproceedings{Paladini2009HLAEGP,
  title={HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia},
  author={Fabiana Paladini and Francesca Belfiore and Elisa Cocco and Carlo Carcassi and Alberto Cauli and Alessandra Vacca and M T Fiorillo and Alessandro Mathieu and Isabella Cascino and Rosa Sorrentino},
  booktitle={Arthritis research & therapy},
  year={2009}
}
INTRODUCTION Ankylosing spondylitis (AS) is a severe, chronic inflammatory disease strongly associated with HLA-B27. The presence of additional HLA risk factors has been suggested by several studies. The aim of the current study is to assess the occurrence of an additional HLA susceptibility locus in the region between HLA-E and HLA-C in the Sardinian population. METHODS 200 random controls, 120 patients with AS and 175 HLA-B27 positive controls were genotyped for six single nucleotide… CONTINUE READING

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