HLA-E/β2 microglobulin overexpression in colorectal cancer is associated with recruitment of inhibitory immune cells and tumor progression.

@article{Bossard2012HLAE2MO,
  title={HLA-E/β2 microglobulin overexpression in colorectal cancer is associated with recruitment of inhibitory immune cells and tumor progression.},
  author={C{\'e}line J Bossard and St{\'e}phane B{\'e}zieau and Tamara Matysiak-Budnik and Christelle Volteau and Christian L. Laboisse and Francine Jotereau and J. -F. Mosnier},
  journal={International journal of cancer},
  year={2012},
  volume={131 4},
  pages={855-63}
}
The host immune response plays a major role in colorectal carcinoma (CRC) progression. A mechanism of tumor immune escape might involve expression of the human leucocyte antigen (HLA)-E/β2m on tumor cells. The inhibitory effect of HLA-E/β2m on CD8+ cytotoxic T lymphocytes and natural killer (NK) cells is mediated by the main HLA-E receptor CD94/NKG2A. As the pathophysiological relevance of this mechanism in CRC remains unknown, this prompted us to examine, in situ, in a series of 80 CRC (i) the… CONTINUE READING
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