HLA-Dr negative acute non-lymphocytic leukemia.

  title={HLA-Dr negative acute non-lymphocytic leukemia.},
  author={John J. Lazarchick and Marbry Hopkins},
  journal={Annals of clinical and laboratory science},
  volume={28 3},
Absent or diminished HLA-Dr antigen representation on the cell surface of both normal and leukemic promyelocytes is a hallmark of this stage of myeloid maturation. In order to document the specificity of this finding for acute promyelocytic leukemia, flow cytometric analysis of leukemic blasts was utilized on 36 cases of acute non-lymphocytic leukemia. All 15 of the promyelocytic leukemias (FAB-M3) studied showed absent or markedly decreased HLA-Dr antigen on their cell surface. However, the… CONTINUE READING


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