HLA Disparity Determines Disease Activity through Pregnancy in Women with Inflammatory Bowel Disease

@article{Kane2004HLADD,
  title={HLA Disparity Determines Disease Activity through Pregnancy in Women with Inflammatory Bowel Disease},
  author={Sunanda Kane and John B. Kisiel and Lorena Shih and Stephen Hanauer},
  journal={American Journal of Gastroenterology},
  year={2004},
  volume={99},
  pages={1523-1526}
}
OBJECTIVES:Inflammatory bowel disease (IBD) activity during pregnancy is variable and factors influencing the course unknown. We studied the relationship between maternal-fetal HLA disparity and IBD course.METHODS:Women with IBD and childbirth were recruited and medical records were reviewed for five time periods. Twenty milliliters of blood was obtained from mother and child for genotyping. Each mother/child pair was assigned an HLA disparity status (±) for HLA A, B, C, DRB1, and DQ loci. Odds… CONTINUE READING
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