HLA-DRhi and CCR9 Define a Pro-Inflammatory Monocyte Subset in IBD

  title={HLA-DRhi and CCR9 Define a Pro-Inflammatory Monocyte Subset in IBD},
  author={Ludvig Bernt Linton and Mats Karlsson and Jeanette Grundstr{\"o}m and Eric Hjalmarsson and Annelie Lindberg and Emma Lindh and Hans Glise and Ragnar Befrits and Izabella Janczewska and Per Karl{\'e}n and Ola Winqvist and M Eberhardson},
  booktitle={Clinical and Translational Gastroenterology},
OBJECTIVES:It has been demonstrated that circulating monocytes relocate to the intestinal mucosa during intestinal inflammation, but the phenotype and inflammatory mechanisms of these monocytes remain poorly understood. Here, we have investigated blood monocytes expressing high levels of HLA-DR and CCR9 in patients with inflammatory bowel disease (IBD).METHODS:Fifty-one patients with mild to severe ulcerative colitis (UC; n=31; UC-DAI 3–12) or Crohn’s disease (CD; n=20; Harvey–Bradshaw indices… CONTINUE READING