HLA-DRB1 gene polymorphism in patients with dilated cardiomyopathy.

  title={HLA-DRB1 gene polymorphism in patients with dilated cardiomyopathy.},
  author={Qiufen Wang and Y Liao and Fang-qi Gong and Huanyuan Mao and Jicheng Zhang},
  journal={Journal of Tongji Medical University = Tong ji yi ke da xue xue bao},
  volume={20 2},
To probe into the genetic background and immunopathogenesis of dilated cardiomyopathy (DCM), HLA-DRB1 gene polymorphism in 68 patients with DCM and 175 normal control subjects were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) techniques. It was found that the frequencies of HLA-DRB1* 15 and HLA-DRB1* 03 alleles were significantly lower in DCM patients than those in normal controls (14.71% vs 29.71% and 4.41% vs 15.43%, respectively), the relative risks (RR… CONTINUE READING