HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.

  title={HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.},
  author={Christian A. Fernandez and Colton A Smith and Wenjian Yang and Mihir Dat{\'e} and Donald Bashford and Eric C. Larsen and W. Paul Bowman and Chengcheng Liu and Laura B Ramsey and Tamara Y Chang and Victoria Kelly Turner and Mignon L Loh and Elizabeth A. Raetz and Naomi Joan Winick and Stephen P Hunger and William L Carroll and Suna Onengut-Gumuscu and Wei-Min Chen and Patrick Concannon and Stephen S. Rich and Paul Scheet and Sima Jeha and Ching-Hon Pui and William E. Evans and Meenakshi Devidas and Mary V. Relling},
  volume={124 8},
Asparaginase is a therapeutic enzyme used to treat leukemia and lymphoma, with immune responses resulting in suboptimal drug exposure and a greater risk of relapse. To elucidate whether there is a genetic component to the mechanism of asparaginase-induced immune responses, we imputed human leukocyte antigen (HLA) alleles in patients of European ancestry enrolled on leukemia trials at St. Jude Children's Research Hospital (n = 541) and the Children's Oncology Group (n = 1329). We identified a… CONTINUE READING