HLA-DRB1, DQA1, DQB1 DNA polymorphism in the Bulgarian population.

  title={HLA-DRB1, DQA1, DQB1 DNA polymorphism in the Bulgarian population.},
  author={Radka Ivanova and E Naoumova and Virginia Lepage and Sami Djoulah and Yordaan Yordanov and M N Loste and Dominique Charron},
  journal={Tissue antigens},
  volume={47 2},
We describe for the first time the use of PCR based techniques to analyze the MHC class II polymorphism of the Bulgarian population. The present study provides the HLA-DRB, DQB1 allele frequencies in 116 Bulgarian individuals and DQA1 alleles frequencies in 100 subjects. DNA from these individuals was typed for DRB and DQB1 typed by the PCR-Allele Specific Amplification (PCR-ASA) method and DQA1 by PCR followed by hybridization using Sequence Specific Oligonucleotides (PCR-SSO). Allele and… CONTINUE READING

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