HLA-DR4 and Gm(1,3;5,21) are associated with U1-nRNP antibody positive connective tissue disease.

@article{Genth1987HLADR4AG,
  title={HLA-DR4 and Gm(1,3;5,21) are associated with U1-nRNP antibody positive connective tissue disease.},
  author={Ekkehard Genth and H Zarnowski and Rudolf Mierau and D Wohltmann and Philipp Hartl},
  journal={Annals of the rheumatic diseases},
  year={1987},
  volume={46 3},
  pages={189-96}
}
Patients with U1-nRNP antibodies (n = 35, 31 female, four male) were typed for HLA-A, -B, -C, and -DR antigens and IgG heavy chain allotypes G1m(1), -(2), -(3), G3m(5), and -(21). The patient group was clinically heterogeneous. Four met the American Rheumatism Association criteria for systemic lupus erythematosus, six for progressive scleroderma, and 14 for rheumatoid arthritis. Sicca syndrome was present in seven cases. Twenty three had overlapping features compatible with mixed connective… CONTINUE READING