HLA-DR3 and DR4 and their relation to the incidence and progression of diabetic retinopathy.

@article{Wong2002HLADR3AD,
  title={HLA-DR3 and DR4 and their relation to the incidence and progression of diabetic retinopathy.},
  author={Tien Yin Wong and Karen J Cruickshank and Ronald Klein and Barbara E. Klein and Scot E. Moss and Mari Palta and William Riley and Noel K. Maclaren and Constance M Vadheim and Jerome I. Rotter},
  journal={Ophthalmology},
  year={2002},
  volume={109 2},
  pages={275-81}
}
PURPOSE Cross-sectional data from the Wisconsin Epidemiologic Study of Diabetic Retinopathy indicated that patients with HLA-DR4, but not DR3, were more likely to have prevalent proliferative retinopathy than those without both antigens. We describe the relation of HLA-DR3 and DR4 antigens to the 14-year incidence and progression of diabetic retinopathy and macular edema in this cohort. DESIGN A population-based cohort study. PARTICIPANTS A probability sample of male and female patients… CONTINUE READING

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The associations did not vary after adjusting for hypertension status , baseline retinopathy , and glycosylated hemoglobin levels , or after stratifying by duration of diabetes ( less than 10 years vs. 10 years or more ) and age at diagnosis of diabetes ( less than 15 years vs. 15 years or more ) .
The associations did not vary after adjusting for hypertension status , baseline retinopathy , and glycosylated hemoglobin levels , or after stratifying by duration of diabetes ( less than 10 years vs. 10 years or more ) and age at diagnosis of diabetes ( less than 15 years vs. 15 years or more ) .
The associations did not vary after adjusting for hypertension status , baseline retinopathy , and glycosylated hemoglobin levels , or after stratifying by duration of diabetes ( less than 10 years vs. 10 years or more ) and age at diagnosis of diabetes ( less than 15 years vs. 15 years or more ) .
The associations did not vary after adjusting for hypertension status , baseline retinopathy , and glycosylated hemoglobin levels , or after stratifying by duration of diabetes ( less than 10 years vs. 10 years or more ) and age at diagnosis of diabetes ( less than 15 years vs. 15 years or more ) .
The discrepancy may be related to increasing homogeneity of retinopathy and diminishing power to detect small differences , but it may also reflect the uncertain and inconsistent effects of HLA - DR3 or DR4 on the development and progression of diabetic retinopathy .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
The discrepancy may be related to increasing homogeneity of retinopathy and diminishing power to detect small differences , but it may also reflect the uncertain and inconsistent effects of HLA - DR3 or DR4 on the development and progression of diabetic retinopathy .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
The discrepancy may be related to increasing homogeneity of retinopathy and diminishing power to detect small differences , but it may also reflect the uncertain and inconsistent effects of HLA - DR3 or DR4 on the development and progression of diabetic retinopathy .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
The discrepancy may be related to increasing homogeneity of retinopathy and diminishing power to detect small differences , but it may also reflect the uncertain and inconsistent effects of HLA - DR3 or DR4 on the development and progression of diabetic retinopathy .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
The discrepancy may be related to increasing homogeneity of retinopathy and diminishing power to detect small differences , but it may also reflect the uncertain and inconsistent effects of HLA - DR3 or DR4 on the development and progression of diabetic retinopathy .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
The discrepancy may be related to increasing homogeneity of retinopathy and diminishing power to detect small differences , but it may also reflect the uncertain and inconsistent effects of HLA - DR3 or DR4 on the development and progression of diabetic retinopathy .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
Fourteen - year incidence and progression of diabetic retinopathy and macular edema based on masked stereoscopic fundus photographic grading
We describe the relation of HLA - DR3 and DR4 antigens to the 14-year incidence and progression of diabetic retinopathy and macular edema in this cohort .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
We describe the relation of HLA - DR3 and DR4 antigens to the 14-year incidence and progression of diabetic retinopathy and macular edema in this cohort .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
There was no relation between HLA - DR3 and DR4 status with the 14-year incidence and progression of diabetic retinopathy , progression to proliferative retinopathy , and incidence of macular edema .
Fourteen - year incidence and progression of diabetic retinopathy and macular edema based on masked stereoscopic fundus photographic grading
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