HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals.

@article{Jaraquemada1990HLADR2aIT,
  title={HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals.},
  author={Dolores Jaraquemada and Roland Martin and Sandra Rosen-Bronson and Marjorie Flerlage and Henry F. McFarland and Eric O Long},
  journal={Journal of immunology},
  year={1990},
  volume={145 9},
  pages={2880-5}
}
The HLA-DR2 restriction of the T cell response to myelin basic protein (MBP) was studied using murine L cells transfected with DRalpha and either DR2a or DR2b beta-chain cDNA. DR2a and DR2b represent the two isotypic DRbeta chains expressed in DR2Dw2 haplotypes. Eleven MBP-specific cytolytic T cell lines derived from patients with multiple sclerosis were isolated. Two of these cell lines recognized MBP-pulsed DR2-expressing L cell transfectants and four of them could only recognize the L cells… CONTINUE READING