HLA-DR1 and HLA-DR3 phenotypes and insulin antibody production in diabetic Sicilian patients.


We have evaluated the role played by HLA antigens in the control of humoral response to exogenous insulin in a sample of Sicilian insulin-dependent diabetes mellitus patients. The results demonstrate that HLA-DR1-positive patients show the highest mean values of insulin antibody, whereas HLA-B18,DR3-positive patients show the lowest. Thus, present… (More)


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