HLA-DR-mediated apoptosis susceptibility discriminates differentiation stages of dendritic/monocytic APC.

@article{Bertho2000HLADRmediatedAS,
  title={HLA-DR-mediated apoptosis susceptibility discriminates differentiation stages of dendritic/monocytic APC.},
  author={Nicolas Bertho and Bernard Dr{\'e}nou and B{\'e}atrice Laup{\`e}ze and Claudine Le Berre and Laurence Amiot and J M Grosset and Olivier Fardel and Dominique Charron and Nuala Mooney and Ren{\'e}e Fauchet},
  journal={Journal of immunology},
  year={2000},
  volume={164 5},
  pages={2379-85}
}
Professional APC are characterized by their ability to present peptide via HLA class II in the presence of costimulatory molecules (CD40, CD80, and CD86). The efficiency of Ag presentation can be classed as follows: mature dendritic cells (DC) are most efficient, immature DC and macrophages are intermediate, and monocytes are considered poor APC. There is a large body of evidence demonstrating that HLA-DR transmits signals in the APC. In this study, we have addressed the question of the outcome… CONTINUE READING

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