HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects naïve to antiretroviral therapy.

@article{Xiao2011HLADREO,
  title={HLA-DR expression on regulatory T cells is closely associated with the global immune activation in HIV-1 infected subjects na{\"i}ve to antiretroviral therapy.},
  author={Jian Xiao and Ke-lei Qian and Qing-hua Cao and Chen-li Qiu and Cao Ting Qiu and Yi-le Xue and Xiao-Yan Zhang and Ping Zhong and Jian-qing Xu and Ming-Yuan Leon Li and Ying Wang},
  journal={Chinese medical journal},
  year={2011},
  volume={124 15},
  pages={
          2340-6
        }
}
BACKGROUND The frequencies of regulatory T cells (Tregs) increased over the HIV infection but its counts actually decreased. We proposed that the decrease of Treg counts may cause the reduction of inhibitory effect and thereby account for the over-activation of Tregs during HIV infection. However, it remains unknown whether Tregs are also over-activated and thereafter the activation induced death may lead to the decrease of Tregs. METHODS Tregs were defined as CD4(+)CD25(+)CD127(lo/-) T cells… CONTINUE READING

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