HLA-DR and ICAM-1 expression on bronchial epithelial cells in asthma and chronic bronchitis.

  title={HLA-DR and ICAM-1 expression on bronchial epithelial cells in asthma and chronic bronchitis.},
  author={Antonio Maurizio Vignola and Alison M. Campbell and Pascal Chanez and Jean Bousquet and P Paul-Lacoste and François B. Michel and Pierre Godard},
  journal={The American review of respiratory disease},
  volume={148 3},
HLA-DR and ICAM-I molecules play an important role in cellular interactions, and their expression can be induced by inflammatory stimuli. We evaluated the spontaneous expression of HLA-DR and ICAM-1 on epithelial cells obtained by bronchial brushing from 27 asthmatic patients, 10 chronic bronchitis (CB) patients, and 19 normal subjects. In all cases > 90% pure epithelial cells were obtained. HLA-DR and ICAM-1 were characterized using monoclonal antibodies and revealed by immunocytochemistry… CONTINUE READING
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