HLA-DR and H-2E transgenes differentially mediate TCR-specific positive selection.

Abstract

The use of HLA transgenic mice in models of immunity and disease assumes that human MHC molecules are able to contribute toward the positive selection of the mouse TCR repertoire. As an initial step towards analysis of this we have compared the relative ability of DR alpha/E beta or E alpha/E beta complexes to induce T cell receptor (TCR) positive selection… (More)

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@article{Elliott1993HLADRAH, title={HLA-DR and H-2E transgenes differentially mediate TCR-specific positive selection.}, author={Justine Elliott and Krisztina Nov{\'a}k - Tak{\'a}cs and Daniel M. Altmann}, journal={International immunology}, year={1993}, volume={5 10}, pages={1279-84} }