HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients.

  title={HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients.},
  author={Emmanuel Mignot and Roza Hayduk and Jed Black and F. Carl Grumet and Christian Guilleminault},
  volume={20 11},
Narcolepsy is a sleep disorder associated with HLA DR15 (DR2) and DQB1*0602. We HLA typed 509 patients enrolled in a clinical trial for the drug modafinil and analyzed the results in relation to cataplexy, a symptom of narcolepsy characterized by muscle weakness triggered by emotions. The patients were either subjects with cataplexy who had a mean sleep latency (SL) of less than 8 minutes and two or more sleep onset rapid eye movement (REM) periods (SOREMPs) during a multiple sleep latency test… CONTINUE READING
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