HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease

  title={HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease},
  author={Rita-D{\'e}sir{\'e}e Jores and F. Frau and F. Cucca and Maria Grazia Clemente and S. Orr{\`u} and M. Rais and S. De Virgiliis and M. Congia},
  journal={Scandinavian Journal of Gastroenterology},
  pages={48 - 53}
  • Rita-Désirée Jores, F. Frau, +5 authors M. Congia
  • Published 2007
  • Medicine
  • Scandinavian Journal of Gastroenterology
  • Objective. Celiac disease (CD) is a T-lymphocyte-mediated small intestinal enteropathy triggered and maintained by dietary gluten, with a strong genetic component mapping to the HLA genes encoding for the class II DQ(α1*0501, β1*02) molecule. Damage of the small intestine may cause a variety of clinical signs ranging from isolated long-standing iron-deficiency anemia refractory to iron supplementation to forms of severe malnutrition that may become life threatening. However, patients carrying… CONTINUE READING
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