HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease

@article{Jores2007HLADQB10201HP,
  title={HLA-DQB1*0201 homozygosis predisposes to severe intestinal damage in celiac disease},
  author={Rita D{\'e}sir{\'e}e Jores and Fulvia Frau and Francesco Cucca and Maria Grazia Clemente and Sandra Orr{\`u} and Marco Rais and Stefano De Virgiliis and Mauro Congia},
  journal={Scandinavian Journal of Gastroenterology},
  year={2007},
  volume={42},
  pages={48 - 53}
}
Objective. Celiac disease (CD) is a T-lymphocyte-mediated small intestinal enteropathy triggered and maintained by dietary gluten, with a strong genetic component mapping to the HLA genes encoding for the class II DQ(α1*0501, β1*02) molecule. Damage of the small intestine may cause a variety of clinical signs ranging from isolated long-standing iron-deficiency anemia refractory to iron supplementation to forms of severe malnutrition that may become life threatening. However, patients carrying… 

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Our knowledge of celiac disease pathogenesis has recently made rapid progress. The disorder is now considered the result of a complex interplay of intrinsic (genetic) and variable extrinsic

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Gene dose effect of the DQB1*0201 allele contributes to severity of coeliac disease

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  • W. VaderD. Stepniak F. Koning
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
Evidence is provided that the disease-associated HLA-DQ2.5 molecule presents a large repertoire of gluten peptides, whereas the non-disease- associated HLA.2.2 molecule can present only a subset ofThese results correlated with peptide binding to the antigen-presenting cells.

The Intestinal T Cell Response to α-Gliadin in Adult Celiac Disease Is Focused on a Single Deamidated Glutamine Targeted by Tissue Transglutaminase

Modifications of anchor residues that lead to an improved affinity for major histocompatibility complex (MHC), and altered conformation of the peptide–MHC complex may be a critical factor leading to T cell responses to gliadin and the oral intolerance of gluten found in CD.