HLA-DQB1*02 dose effect on RIA anti-tissue transglutaminase autoantibody levels and clinicopathological expressivity of celiac disease.

@article{Nenna2008HLADQB102DE,
  title={HLA-DQB1*02 dose effect on RIA anti-tissue transglutaminase autoantibody levels and clinicopathological expressivity of celiac disease.},
  author={Raffaella Nenna and B{\'a}rbara P{\'e}rez Mora and Francesca Megiorni and Maria Cristina Mazzilli and Fabio Massimo Magliocca and Claudio Tiberti and Margherita Bonamico},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={2008},
  volume={47 3},
  pages={
          288-92
        }
}
OBJECTIVES Celiac disease is an autoimmune enteropathy caused by gluten ingestion in genetically susceptible individuals. Anti-transglutaminase autoantibody (tTGAb) assay is useful to detect candidates undergoing intestinal biopsy. Our aim was to investigate whether the DQB1*02 allele could influence tTGAb titers and the clinicopathological expressivity of the disease. METHODS A total of 124 patients with celiac disease, tested for RIA tTGAb at diagnosis, were typed for HLA-DRB1, -DQA1, and… CONTINUE READING
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