HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants

  title={HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants},
  author={Graham A Heap and M. N. Weedon and Claire M Bewshea and Abhey Singh and Mian Chen and Jack B Satchwell and Julian P. Vivian and Kenji So and Patrick C A Dubois and J M Andrews and Vito Annese and Peter A. Bampton and Martin C. N. M. Barnardo and Sally J. Bell and Andy Cole and Susan J. Connor and Tom J Creed and Fraser R Cummings and Mauro D'Amato and Tawfique K Daneshmend and Richard N Fedorak and Timothy H. J. Florin and Daniel R. Gaya and Emma Greig and Jonas Halfvarson and Alisa Hart and Peter Miles Irving and Gareth Jones and Amir S Karban and Ian Craig Lawrance and James C. Lee and Charlie W. Lees and Raffi Lev-Tzion and James Oliver Lindsay and John C. Mansfield and Joel Mawdsley and Zia Mazhar and M. B. A. Parkes and Kirstie S Parnell and Timothy R. Orchard and Graham L Radford-Smith and Richard Russell and David M Reffitt and Jack Satsangi and Mark S. Silverberg and Giacomo carlo Sturniolo and Mark Tremelling and Epameinondas Tsianos and David A van Heel and Alissa J. Walsh and Gill A Watermeyer and Rinse Karel Weersma and Sebastian Zeissig and Jamie Rossjohn and Arthur L. Holden and Tariq Ahmad},
  journal={Nature Genetics},
Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory bowel disease (IBD) who had developed pancreatitis within 3 months of starting these drugs from 168 sites around the world. After detailed case adjudication, we performed a genome-wide association study on 172 cases and 2,035 controls with IBD. We identified strong… CONTINUE READING
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a randomized controlled trial

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