HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.

@article{Kelemen2004HLADQ8associatedTC,
  title={HLA-DQ8-associated T cell responses to the diabetes autoantigen phogrin (IA-2 beta) in human prediabetes.},
  author={Katalin Kelemen and Peter A. Gottlieb and Amy L. Putnam and Howard W Davidson and Dale R. Wegmann and John C. Hutton},
  journal={Journal of immunology},
  year={2004},
  volume={172 6},
  pages={
          3955-62
        }
}
Susceptibility to type 1A autoimmune diabetes is linked to expression of particular MHC class II molecules, notably HLA-DQ8 in man and the orthologous I-Ag7 in the nonobese diabetic mouse. In the present study, we analyzed two peptide epitopes (peptides 2 and 7) from the diabetes autoantigen phogrin (IA-2beta), in the context of their presentation by the I-Ag7 and HLA-DQ8 molecules and their role as potential T cell antigenic epitopes in human diabetes. Both of these peptides are targets of… CONTINUE READING

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