HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22

@article{Bodd2010HLADQ2restrictedGT,
  title={HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22},
  author={Michael Bodd and Melinda R{\'a}ki and Stig Tollefsen and L E Fallang and Elin Bergseng and Knut Erik Aslaksen Lundin and Ludvig M. Sollid},
  journal={Mucosal Immunology},
  year={2010},
  volume={3},
  pages={594-601}
}
We have analyzed the production of the effector cytokines interleukin (IL)-17, IL-21, and IL-22 in gluten-reactive CD4+ T cells of celiac disease patients, either cultured from small intestinal biopsies or isolated from peripheral blood after an oral gluten challenge. Combining intracellular cytokine staining with DQ2-α-II gliadin peptide tetramer staining of intestinal polyclonal T-cell lines, we found that gluten-specific T cells produced interferon-γ (IFN-γ) and IL-21, but not IL-17 or IL-22… CONTINUE READING