HLA-DQ polymorphisms are highly selective for peptide binding interactions.

  title={HLA-DQ polymorphisms are highly selective for peptide binding interactions.},
  author={William W Kwok and Gerald T Nepom and François Raymond},
  journal={Journal of immunology},
  volume={155 5},
The impact of HLA-DQ allelic polymorphism on peptide binding interactions was investigated. MHC class II binding peptides from lambda repressor (lambda R), thyroid peroxidase (TPO), and a modified poly-alanine peptide (AKY) were used in two different binding assays, one with purified DQ molecules and another with cells that expressed DQ cell surface dimers. Class II heterodimers of different combinations of DQ alpha-chain and the DQ beta-chain independently influenced specific peptide… CONTINUE READING


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