HLA-DQ genotypes are associated with autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes mellitus patients.

@article{Serjeantson1993HLADQGA,
  title={HLA-DQ genotypes are associated with autoimmunity to glutamic acid decarboxylase in insulin-dependent diabetes mellitus patients.},
  author={Susan W. Serjeantson and Jennifer Court and Ian R. Mackay and Bronwyn A. Matheson and Merrill J. Rowley and Tiinamaija Tuomi and Jon D Wilson and Paul Zev Zimmet},
  journal={Human immunology},
  year={1993},
  volume={38 2},
  pages={97-104}
}
This study has investigated the genetic basis of the heterogeneous autoimmune response to glutamic acid decarboxylase (GAD) in 179 Australian patients with IDDM. Antibodies to GAD have been correlated with HLA-DQB1 alleles and genotypes, as determined by sequence-specific oligonucleotide hybridizations after polymerase chain reaction was applied to exon 2 of the DQ beta 1 gene. HLA-DQ2 was significantly increased (p < 0.01) in IDDM patients with antibodies to GAD. Antibodies to GAD were… CONTINUE READING

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