HLA-DQ association and allele competition in Chinese narcolepsy.

  title={HLA-DQ association and allele competition in Chinese narcolepsy.},
  author={Fang Han and Lijin Lin and Jingbo Li and Song X. Dong and Ping Nicole An and Liansheng Zhao and Nan Liu and Q. Y. Li and Hai-Fei Yan and Zhan Cheng Gao and Juliette Faraco and Kingman P Strohl and X Liu and Hiroko Miyadera and Emmanuel Mignot},
  journal={Tissue antigens},
  volume={80 4},
In Japanese, Koreans and Caucasians, narcolepsy/hypocretin deficiency is tightly associated with the DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype. Studies in African-Americans suggest a primary effect of DQB1*06:02, but this observation has been difficult to confirm in other populations because of high linkage disequilibrium between DRB1*15:01/3 and DQB1*06:02 in most populations. In this study, we studied human leucocyte antigen (HLA) class II in 202 Chinese narcolepsy patients (11% from South… CONTINUE READING
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