HLA-DQ allele competition in narcolepsy: a comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.

@article{Ollila2015HLADQAC,
  title={HLA-DQ allele competition in narcolepsy: a comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe.},
  author={Hanna Maria Ollila and Marcelo A. Fernandez-Vi{\~n}a and Emmanuel Mignot},
  journal={Sleep},
  year={2015},
  volume={38 1},
  pages={
          147-51
        }
}
STUDY OBJECTIVES Although HLA-DQB1*06:02 is the strongest predisposing genetic factor for narcolepsy, the effect of this gene must be considered alongside that of its polymorphic partner, DQA1. In this paper, we extend an analysis of the effect of HLA-DQB1 on narcolepsy risk published recently by Tafti et al. RESULTS Imputing allelic variation at the level of HLA-DQA1, we show that this locus also has a considerable effect on disease susceptibility. Our data are also compatible with previous… CONTINUE READING