HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

@article{Todd1987HLADQGC,
  title={HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus},
  author={John A. Todd and John I. Bell and Hugh O Mcdevitt},
  journal={Nature},
  year={1987},
  volume={329},
  pages={599-604}
}
Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles ofHLA-DQβ determine both disease susceptibility and resistance, and that the structure of the DQ molecule, in particular residue 57 of the β-chain, specifies the autoimmune response against the insulin-producing islet cells.