HLA-DQβ Typing and Non-Asp57 Alleles in IDDM and Nondiabetic Subjects in New Zealand

@article{Forbes1993HLADQTA,
  title={HLA-DQβ Typing and Non-Asp57 Alleles in IDDM and Nondiabetic Subjects in New Zealand},
  author={L. Forbes and L. Brown and R. Scott},
  journal={Diabetes Care},
  year={1993},
  volume={16},
  pages={1179 - 1183}
}
  • L. Forbes, L. Brown, R. Scott
  • Published 1993
  • Medicine
  • Diabetes Care
  • OBJECTIVE To determine the frequency of IDDM risk-associated HLA-DQβ alleles in New Zealanders with IDDM and nondiabetic control subjects, and to examine these as susceptibility markers in relation to IDDM incidence. RESEARCH DESIGN AND METHODS HLA-DQβ typing was conducted in 55 juvenile-onset IDDM subjects diagnosed between 1990 and 1992, and 53 nondiabetic control subjects. Allele typing was conducted by a polymerase chain reaction-restriction fragment-length polymorphism technique. All… CONTINUE READING
    15 Citations

    Figures, Tables, and Topics from this paper

    HLA-DQβl Typing and Non-Asp57 Alleles in the Aborigine Population of Senegal
    • 8
    Rapid HLA-DQB1 Genotyping for Four Alleles in the Assessment of Risk for IDDM in the Finnish Population
    • 143
    Complex interaction between HLA DR and DQ in conferring risk for childhood type 1 diabetes.
    • 91

    References

    SHOWING 1-10 OF 31 REFERENCES
    HLA-DQA1 and DQB1 alleles in French and Algerian type 1 diabetic subjects.
    • 4
    HLA-DQB1 Alleles and Absence of Asp 57 as Susceptibility Factors of IDDM in Finland
    • 66
    • Highly Influential
    The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.
    • 110
    • PDF
    Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain.
    • 224
    • Highly Influential
    • PDF
    High Frequency of Aspartic Acid at Position 57 of HLA-DQ β-Chain in Japanese IDDM Patients and Nondiabetic Subjects
    • 115
    • PDF
    A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.
    • 266
    Rapid Detection of IDDM Susceptibility With HLA-DQ β-Alleles as Markers
    • 37
    HLA-DQ rather than HLA-DR region might be involved in dominant nonsusceptibility to diabetes.
    • 44
    • PDF