HLA DPA1, DPB1 Alleles and Haplotypes Contribute to the Risk Associated With Type 1 Diabetes

@inproceedings{Varney2010HLADD,
  title={HLA DPA1, DPB1 Alleles and Haplotypes Contribute to the Risk Associated With Type 1 Diabetes},
  author={Michael D. Varney and Ana M Valdes and Joyce A. Carlson and Janelle A. Noble and Brian D. Tait and Persia Bonella and Eva Lavant and Anna Lisa Fear and Anthony Louey and Priscilla V Moonsamy and Josyf C Mychaleckyj and Henry A. Erlich},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE To determine the relative risk associated with DPA1 and DPB1 alleles and haplotypes in type 1 diabetes. RESEARCH DESIGN AND METHODS The frequency of DPA1 and DPB1 alleles and haplotypes in type 1 diabetic patients was compared to the family based control frequency in 1,771 families directly and conditional on HLA (B)-DRB1-DQA1-DQB1 linkage disequilibrium. A relative predispositional analysis (RPA) was performed in the presence or absence of the primary HLA DR-DQ associations and the… CONTINUE READING

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