HLA DNA typing: past, present, and future.

  title={HLA DNA typing: past, present, and future.},
  author={Henry A. Erlich},
  journal={Tissue antigens},
  volume={80 1},
The human leukocyte antigen (HLA) class I and class II loci are the most polymorphic genes in the human genome, with a highly clustered and patchwork pattern of sequence motifs. In the three decades since the first HLA gene was isolated by molecular cloning (a cDNA clone of HLA-B7), thousands of alleles have been identified and the names and sequences of all known alleles have been curated in the IMGT/HLA database. This extensive allelic diversity made and continues to make high-resolution HLA… CONTINUE READING
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