HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

@article{Colonna1993HLACIT,
  title={HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.},
  author={Marco Colonna and Giovanna Borsellino and Michela Falco and Giovanni Battista Ferrara and Jack Leonard Strominger},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 24},
  pages={12000-4}
}
Natural killer (NK) cells recognize alloantigens on normal cells. One of these alloantigens correlates with homozygosity for a dimorphism of HLA-C at positions 77-80, which is shared by a number of HLA-C alleles. A second allelic alloantigen correlates with homozygosity for the alternative HLA-C dimorphism, which is shared by the remaining HLA-C alleles. Moreover, NK1- and NK2-specific NK cell lines can be generated by mixed leukocyte cultures in which donor and stimulator are homozygous for… CONTINUE READING
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