HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C

@article{Thomas2009HLACCS,
  title={HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C},
  author={Rasmi Thomas and Richard Apps and Ying Qi and Xiaojiang Gao and Victoria Male and Colm O'huigin and Geraldine M. O'Connor and Dongliang Ge and Jacques Fellay and Jeffrey N Martin and Joseph B. Margolick and James Jerome Goedert and Susan P Buchbinder and Gregory D Kirk and Maureen P. Martin and Amalio Telenti and Steven G. Deeks and Bruce D. Walker and David W. Goldstein and Daniel W McVicar and Ashley Moffett and Mary N Carrington},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={1290-1294}
}
A variant 35 kb upstream of the HLA-C gene (-35C/T) was previously shown to associate with HLA-C mRNA expression level and steady-state plasma HIV RNA levels. We genotyped this variant in 1,698 patients of European ancestry with HIV. Individuals with known seroconversion dates were used for disease progression analysis and those with longitudinal viral load data were used for viral load analysis. We further tested cell surface expression of HLA-C in normal donors using an HLA-C-specific… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS