HLA-B8,DR3 phenotype and the antibody response against Epstein-Barr virus.

  title={HLA-B8,DR3 phenotype and the antibody response against Epstein-Barr virus.},
  author={Calogero Caruso and G Candore and Antonio Tobia Colucci and Diego Cigna and Francesca Sammartano and Pietro Ammatuna},
  journal={Immunological investigations},
  volume={22 1},
Antibodies against the viral capsid antigen (VCA) and nuclear antigens (EBNAs) of the Epstein-Barr virus (EBV) were determined in a sample of Sicilian population. A significant correlation was observed between HLA-B8,DR3 phenotype and reduced titres of antibodies to EBNAs, whereas HLA-B8,DR3 positive individuals displayed levels of antibodies to VCA comparable to those of HLA-B8,DR3 negative ones. These results further strengthen the suggestion that HLA-B8,DR3 positive subjects are low… CONTINUE READING

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