HLA-B7-restricted EBV-specific CD8+ T cells are dysregulated in multiple sclerosis.

@article{Jilek2012HLAB7restrictedEC,
  title={HLA-B7-restricted EBV-specific CD8+ T cells are dysregulated in multiple sclerosis.},
  author={Samantha Jilek and Myriam Schluep and Alexandre Harari and Mathieu Canales and Andreas P Lysandropoulos and Anastasia Zekeridou and Giuseppe Pantaleo and Renaud A Du Pasquier},
  journal={Journal of immunology},
  year={2012},
  volume={188 9},
  pages={
          4671-80
        }
}
It was hypothesized that the EBV-specific CD8(+) T cell response may be dysregulated in multiple sclerosis (MS) patients, possibly leading to a suboptimal control of this virus. To examine the CD8(+) T cell response in greater detail, we analyzed the HLA-A2-, HLA-B7-, and HLA-B8-restricted EBV- and CMV-specific CD8(+) T cell responses in a high number of MS patients and control subjects using tetramers. Content in cytolytic granules, as well as cytotoxic activity, of EBV- and CMV-specific CD8… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 58 REFERENCES

Intrathecal immune responses to EBV in early MS.

  • European journal of immunology
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies.

  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2012

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