HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition.

@article{Miura2009HLAB57B5801HI,
  title={HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition.},
  author={Toshiyuki Miura and Mark A Brockman and Arne Schneidewind and Michael A. Lobritz and Florencia Pereyra and Almas Rathod and Brian L Block and Zabrina L. Brumme and Chanson J. Brumme and Brett M. Baker and Alissa C. Rothchild and Bin Li and Alicja K. Trocha and Emily Cutrell and Nicole Frahm and Christian Brander and Ildik{\'o} T{\'o}th and Eric J. Arts and Todd M. Allen and Bruce D. Walker},
  journal={Journal of virology},
  year={2009},
  volume={83 6},
  pages={2743-55}
}
Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below the limit of commercial assay detection (<50 RNA copies/ml) in the absence of antiviral therapy, but the mechanisms of control remain unclear. HLA-B57 and the closely related allele B*5801 are particularly associated with enhanced control and recognize the same Gag(240-249) TW10 epitope. The typical escape mutation (T242N) within this epitope diminishes viral replication capacity in chronically infected… CONTINUE READING