HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain.

@article{Hayashi1989HLAB51AH,
  title={HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain.},
  author={Hideyuki Hayashi and Peter D. Ennis and Hiroyoshi Ariga and Russell D. Salter and Peter Parham and Kyoichi Kano and Masafumi Takiguchi},
  journal={Journal of immunology},
  year={1989},
  volume={142 1},
  pages={306-11}
}
Genes encoding the serologically cross-reactive HLA-B51 and HLA-Bw52 molecules were isolated and the exons sequenced. HLA-B51 genes obtained from Caucasian and Oriental individuals were identical. HLA-Bw52 differs from HLA-B51 by four nucleotide substitutions in exon 2 encoding the alpha 1 domain. These comprise one isolated silent substitution in codon 23 and a cluster of three coding substitutions in codons 63 and 67. Amino acid substitutions of N----E at position 63 and F----S at position 67… CONTINUE READING