HLA-B27 lacking associated beta2-microglobulin rearranges to auto-display or cross-display residues 169-181: a novel molecular mechanism for spondyloarthropathies.

@article{LuthraGuptasarma2004HLAB27LA,
  title={HLA-B27 lacking associated beta2-microglobulin rearranges to auto-display or cross-display residues 169-181: a novel molecular mechanism for spondyloarthropathies.},
  author={Manni Luthra-Guptasarma and Balvinder Singh},
  journal={FEBS letters},
  year={2004},
  volume={575 1-3},
  pages={1-8}
}
Expression of the MHC class I allele, HLA-B27, is correlated with autoimmune disease. The misfolding and association of B27 heavy chains through non-native disulfide bonds has recently been implicated. Here, we propose that beta2m-free, peptide-free heavy chains support a helix-coil transition in the segment leading from the alpha2 domain to the alpha3… CONTINUE READING