HLA-B27 heavy chains distinguished by a micropolymorphism exhibit differential flexibility.

@article{Fabian2010HLAB27HC,
  title={HLA-B27 heavy chains distinguished by a micropolymorphism exhibit differential flexibility.},
  author={Heinz Fabian and H. -J. Huser and Bernhard Loll and Andreas Ziegler and Dieter Naumann and Barbara Uchańska-Ziegler},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 4},
  pages={978-87}
}
OBJECTIVE Although the products of the HLA subtypes B*2705 and B*2709 differ only in residue 116 (Asp versus His) within their peptide-binding grooves, they are differentially associated with inflammatory rheumatic diseases such as ankylosing spondylitis (AS): B*2705 occurs in AS patients, whereas B*2709 is only rarely encountered. The reasons for this distinct association are still unclear but could include subtype-specific conformational and dynamic properties of these antigens. The present… CONTINUE READING

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