HLA-B27 alters the response to tumor necrosis factor α and promotes osteoclastogenesis in bone marrow monocytes from HLA-B27-transgenic rats.

@article{LayhSchmitt2013HLAB27AT,
  title={HLA-B27 alters the response to tumor necrosis factor α and promotes osteoclastogenesis in bone marrow monocytes from HLA-B27-transgenic rats.},
  author={Gerlinde Layh-Schmitt and Eva Y Yang and Grace Kwon and Robert A. Colbert},
  journal={Arthritis and rheumatism},
  year={2013},
  volume={65 8},
  pages={2123-31}
}
OBJECTIVE To determine whether HLA-B27 expression alters the response of bone marrow monocytes from HLA-B27/human β2 -microglobulin-transgenic (B27-Tg) rats to tumor necrosis factor α (TNFα) and, if so, whether this affects the cells involved in bone homeostasis. METHODS Bone marrow monocytes were treated with RANKL or with TNFα to promote osteoclast formation. Osteoclasts were quantified by counting. Gene expression was measured using quantitative polymerase chain reaction analysis, and… CONTINUE READING
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