HLA-B27: portraying immunodominant viral epitopes.

  title={HLA-B27: portraying immunodominant viral epitopes.},
  author={Jos{\'e} A L{\'o}pez de Castro},
  journal={European journal of immunology},
  volume={35 2},
Although the crystal structure of HLA-B27 has been known for a long time, only recently have X-ray diffraction studies of this molecule in complex with individual peptides become available. The report of three such structures involving viral epitopes that are immunodominant in HLA-B27-restricted T cell responses against influenza, Epstein-Barr and HIV viruses significantly improves our perception of critical aspects of the immunological and pathogenetic roles of HLA-B27, including (1) the… CONTINUE READING