HLA-B genotyping to detect carbamazepine-induced Stevens-Johnson syndrome: implications for personalizing medicine.

@article{Hung2005HLABGT,
  title={HLA-B genotyping to detect carbamazepine-induced Stevens-Johnson syndrome: implications for personalizing medicine.},
  author={Shuen-Iu Hung and Wen-Hung Chung and Yuan-Tsong Chen},
  journal={Personalized medicine},
  year={2005},
  volume={2 3},
  pages={225-237}
}
Preventing severe adverse drug reactions by identifying people at risk with a simple genetic test is the goal of many pharmacogenomic studies. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are related, life-threatening cutaneous adverse reactions, most often caused by medication. The overall incidence and the commonly offending drugs vary among different ethnic populations. Susceptibility to such idiosyncratic reactions is thought to be genetically determined and immune… CONTINUE READING

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