HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.

@article{Hung2005HLAB5801AA,
  title={HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.},
  author={Shuen-Iu Hung and Wen-Hung Chung and L B Liou and C-C Chu and Marie Lin and Hsien Ping Huang and Yen-Ling Lin and Joung-Liang Lan and Li‐Cheng Yang and H S Hong and Ming-jing Chen and Ping Chin Lai and Mai-Szu Wu and C Y Chu and Kuo‐Hsien Wang and Chien-Hsiun Chen and Cathy S. J. Fann and Jer-Yuarn Wu and Yuan-Tsong Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 11},
  pages={
          4134-9
        }
}
  • S. Hung, W. Chung, Yuan-Tsong Chen
  • Published 15 March 2005
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry significant morbidity and mortality. To identify genetic markers for allopurinol-SCAR, we carried out a case-control association study. We enrolled 51 patients with allopurinol-SCAR and 228 control… 

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Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population
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HLA-B*58:01 for Allopurinol-Induced Cutaneous Adverse Drug Reactions: Implication for Clinical Interpretation in Thailand
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HLA‐B*58:01 is strongly associated with allopurinol‐induced severe cutaneous adverse reactions in Han Chinese patients: a multicentre retrospective case–control clinical study
TLDR
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HLA-B genotyping to detect carbamazepine-induced Stevens-Johnson syndrome: implications for personalizing medicine.
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Finding a strong genetic association between a particular human leukocyte antigen (HLA)-B allele and the reaction to a specific drug provides evidence that the pathogenesis of the severe cutaneous adverse drug reactions involves major histocompatibility complex-restricted presentation of a drug or its metabolites for T-cell activation.
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