HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.

@article{Hung2005HLAB5801AA,
  title={HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol.},
  author={Shuen-Iu Hung and Wen-Hung Chung and L B Liou and C-C Chu and Marie Lin and Hsien Ping Huang and Yen-Ling Lin and Joung-Liang Lan and Li‐Cheng Yang and H S Hong and Ming-jing Chen and Ping Chin Lai and Mai-Szu Wu and C Y Chu and Kuo‐Hsien Wang and Chien-Hsiun Chen and Cathy S. J. Fann and Jer-Yuarn Wu and Yuan-Tsong Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 11},
  pages={
          4134-9
        }
}
  • S. Hung, W. Chung, Yuan-Tsong Chen
  • Published 15 March 2005
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. The adverse events are unpredictable and carry significant morbidity and mortality. To identify genetic markers for allopurinol-SCAR, we carried out a case-control association study. We enrolled 51 patients with allopurinol-SCAR and 228 control… 
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Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population
TLDR
It is suggested that HLA-B*5801 is a valid genetic marker for screening Thai individuals who may be at risk for allopurinol-induced life-threatening SJS and TEN.
Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans
TLDR
Strong positive association of HLA-B*5801 and negative association ofHLA-A*0201 with the development of allopurinol-induced SCARs in the Korean population is found.
Allopurinol-induced severe cutaneous adverse reactions: A report of three cases with the HLA-B*58:01 allele who underwent lymphocyte activation test
TLDR
It is suggested that patients with HLA-B*58:01 may develop SCARs upon allopurinol administration, and Hla-B genotyping could be helpful in preventing serious problems attributable to allopURinol treatment, although PCR-SBT HLA -B genotypesing is time consuming.
Predominant HLA Alleles and Haplotypes in Mild Adverse Drug Reactions Caused by Allopurinol in Vietnamese Patients with Gout
TLDR
Although HLA-B*58:01 may be a cause for the occurrence of MCARs in patients with gout, this correlation was not as strong as that previously reported in Patients with SCAR.
HLA Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population
TLDR
Based on the frequencies of HLA pharmacogenetic markers, Thai and other Southeast Asian populations may be at higher risk of drug-induced SCARs compared with Caucasian population.
Impact of HLA-B*58:01 allele and allopurinol-induced cutaneous adverse drug reactions: evidence from 21 pharmacogenetic studies
TLDR
Allopurinol–SCAR is strongly associated with HLA-B*58:01, and HLA:01 is a highly specific and effective genetic marker for the detection allopur inol-induced CADRs, especially for Asian descents.
Impact of the HLA-B(*)58:01 Allele and Renal Impairment on Allopurinol-Induced Cutaneous Adverse Reactions.
HLA-B*58:01 for Allopurinol-Induced Cutaneous Adverse Drug Reactions: Implication for Clinical Interpretation in Thailand
TLDR
It is suggested that screening for HLA-B*58:01 alleles in patients who will be treated with allopurinol would be clinically helpful in preventing the risk of developing CARD in a Thai patients.
HLA‐B*58:01 is strongly associated with allopurinol‐induced severe cutaneous adverse reactions in Han Chinese patients: a multicentre retrospective case–control clinical study
TLDR
A multicentre retrospective case–control study of Han Chinese patients to elucidate the relationship between allopurinol-induced SCARs and HLA-B alleles and found that SJS and TEN are more severe reactions and commonly overlap in the clinic.
HLA-B genotyping to detect carbamazepine-induced Stevens-Johnson syndrome: implications for personalizing medicine.
TLDR
Finding a strong genetic association between a particular human leukocyte antigen (HLA)-B allele and the reaction to a specific drug provides evidence that the pathogenesis of the severe cutaneous adverse drug reactions involves major histocompatibility complex-restricted presentation of a drug or its metabolites for T-cell activation.
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