HLA-B*5701 typing by sequence-specific amplification: validation and comparison with sequence-based typing.

@article{Martn2005HLAB5701TB,
  title={HLA-B*5701 typing by sequence-specific amplification: validation and comparison with sequence-based typing.},
  author={A. Maldonado Mart{\'i}n and David N Nolan and Simon A Mallal},
  journal={Tissue antigens},
  year={2005},
  volume={65 6},
  pages={571-4}
}
Susceptibility to abacavir hypersensitivity (ABC HSR) is strongly associated with alleles carried on the 57.1 ancestral haplotype including HLA-B*5701 and Hsp70 Hom M493T. In one study, prospective testing for HLA-B*5701 and exclusion of individuals carrying this allele, from receiving abacavir, substantially lowered the incidence of ABC HSR to 0% (95% confidence interval 0-0.075%). The presence of HLA-B*5701 is usually detected by standard serological tests and by molecular genetic methods… CONTINUE READING
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