HLA-B*5101 in Greek patients with Behçet's disease.

  title={HLA-B*5101 in Greek patients with Behçet's disease.},
  author={Yvonni Koumantaki and C Stavropoulos and Marilyn Spyropoulou and H Messini and M Papademetropoulos and Ernestini Giziaki and N Marcomichelakis and G D Palimeris and P. Kaklamanis and Evangelia Kaklamani},
  journal={Human immunology},
  volume={59 4},
Frequency of HLA-B51 in Behçet's Patients and Relationship with Clinical Findings
No statistically significant correlation was found between HLA-B51 positivity and demographic and clinical findings of Behçet patients and there is a need for larger comparative prospective studies investigating the relationship between Hla-B 51 and BD in different ethnic groups.
HLA-B*27 allele associated to Behçet's disease and to anterior uveitis in Moroccan patients.
A significant increased frequency of the HLA-B*27 allele was found in Moroccans patients with Behçet's disease when compared to controls, and particularly in the patients who presented an anterior uveitis.
HLA-B51 and its allelic types in association with Behçet's disease and recurrent aphthous stomatitis in Korea.
The BD patients with B51 seemed to be susceptible for manifesting uveitis, erythema nodosum, and the full-blown syndrome as complete BD, therefore the presence of HLA-B51 antigen in BD patients would be a genetic marker for the severe disease.
Re-evaluation of heterogeneity in HLA-B*510101 associated with Behçet's disease.
It was found that all the patients and healthy controls carried B*510101 with no variation in the 5'-flanking region, exon and intron, and phylogenetic analyses of B* 510101 showed that the 3'-flank sequences followed an evolutional divergence differently from that of the other regions, implying that a unifying selection might operate to conserve B*500101.
Association of MICA gene and HLA-B*5101 with Behçet's disease in Greece.
Investigating microsatellite polymorphism in Greek patients with Behçet's disease revealed a strong association of BD with a particular MICA-TM allele, A6, providing insight into the molecular mechanism underlying the development of BD.
[HLA polymorphism and Behçet's disease in Moroccan population].
Contribution of Hla-B51 in the susceptibility and specific clinical features of Behcet's disease in Tunisian patients.
HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behçet's disease.
In this population of Middle Eastern descent, the HLA*B51 family of alleles is a strong risk factor for BD, and in particular the development of ocular disease, and a primary role for TNF gne polymorphisms in BD was not identified, but co-expression of the TNFB*2 allele with HLA-B*51 may contribute to severity of Ocular disease.
A comprehensive overview on the genetics of Behçet's disease
It is suggested that immune responses to the pathogen as an important environmental factor and mucosal immunity contribute to Behçet's disease susceptibility.


A complete type patient with Behçet's disease associated with HLA‐B*5102
One B51-positive patient who was definitely diagnosed as BD is reported on, and who exhibited the HLA-B*5102 allele in the expanded study.
Immunogenetic studies of Behçet's disease.
Current data on genetic factors involved in the development of Behçet's disease are reviewed and it is believed that many important genes exist in the region located between the TNF and HLA-B or Hla-C genes, including the MIC, PERB, and NOB genes.
HLA-DRB1 alleles in Greek rheumatoid arthritis patients and their association with clinical characteristics.
The association of certain HLA-DRB1 alleles in Green rheumatoid arthritis patients with several features of the disease, the gender of the patient and the age at onset was investigated and Hla-DR4 was significantly increased in RA patients.
Human leukocyte antigen serologic and DNA typing of Behçet's disease and its primary association with B51.
Results indicated that the primary and primordial gene(s) responsible for the susceptibility to BD were not located in the HLA class II gene region but were in or very close to the Hla-B locus in the class I region, and suggested the possibility that BD was a symptom complex associated with some independent diseases.
Parvovirus B19 infection in Behçet's disease
The findings do not strongly support the involvement of B19 in the pathogenesis of Behçet's disease and the serological evidence of acute infection in 6 BD patients may be purely coincidental.
Association of HLA-B51 and lack of association of class II alleles with Behçet's disease.
B51 was found to be a genetic marker most strongly associated with Behcet's disease and the positive and negative associations of class II alleles with the disease can be explained by linkage disequilibrium with B51, and do not reach statistical significance by the corrected p-value test.
The place of Behçet's syndrome among the autoimmune diseases.
  • H. Yazici
  • Medicine, Biology
    International reviews of immunology
  • 1997
The value of immunological data on BS will much increase of the authors include in each experiment patients with classic autoimmune diseases along with "pure" inflammatory conditions like gout and infectious diseases.
Lack of association between Behçet's disease and major histocompatibility complex class II antigens in an ethnically diverse North American Caucasoid patient group.
A group of 25 North American Caucasoid patients with well defined Behcet's disease were serologically typed for HLA-DR and DQw antigens. No significant associations were seen when results were