HLA-B*13:01 and the dapsone hypersensitivity syndrome.

  title={HLA-B*13:01 and the dapsone hypersensitivity syndrome.},
  author={F. Zhang and H. Liu and A. Irwanto and X. Fu and Y. Li and Gq Yu and Y-X Yu and M-F Chen and H-Q Low and J-H Li and F-F Bao and J. N. Foo and Jx Bei and X-M Jia and J. Liu and H. Liany and N. Wang and G.-Y. Niu and Z. Wang and B.-Q. Shi and H-Q Tian and S-S Ma and Y. Zhou and J-B You and Q. Yang and C. Wang and T. Chu and Dc Liu and X-L Yu and Y. Sun and Y. Ning and Zh. Wei and S-L Chen and X. Chen and Z. Zhang and Y. Liu and S. Pulit and W. Wu and Z. Zheng and R. Yang and H. Long and Z-S Liu and J. Wang and M. Li and L. Zhang and H. Wang and L. M. Wang and P. Xiao and J.-L. Li and Z-m Huang and J-X Huang and Z. Li and L. Xiong and J. Yang and X-D Wang and Db Yu and X.-M. Lu and G-Z Zhou and L-B Yan and J. Shen and G.-C. Zhang and Yx Zeng and P. D. de Bakker and S. Chen},
  journal={The New England journal of medicine},
  volume={369 17},
  • F. Zhang, H. Liu, +63 authors J. Liu
  • Published 2013
  • Medicine
  • The New England journal of medicine
  • BACKGROUND Dapsone is used in the treatment of infections and inflammatory diseases. The dapsone hypersensitivity syndrome, which is associated with a reported mortality of 9.9%, develops in about 0.5 to 3.6% of persons treated with the drug. Currently, no tests are available to predict the risk of the dapsone hypersensitivity syndrome. METHODS We performed a genomewide association study involving 872 participants who had received dapsone as part of multidrug therapy for leprosy (39… CONTINUE READING
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