HLA-A2 reactive antibodies in a patient who types as HLA-A2: The importance of high resolution typing and epitope-based antibody analysis.

Abstract

This report describes a case of a highly sensitized patient who had serum antibodies reacting with HLA-A2 but whose phenotype included HLA-A2. The determination of HLA mismatch acceptability at the antigen level was problematic, but high-resolution HLA typing information and epitope-based antibody specificity analysis based on the nonself-self paradigm of HLA epitope immunogenicity have provided a solution. This case supports the concept that HLA typing at the allele level offers a better approach to identifying suitable donors for sensitized patients.

DOI: 10.1016/j.trim.2015.04.001

Cite this paper

@article{Hahn2015HLAA2RA, title={HLA-A2 reactive antibodies in a patient who types as HLA-A2: The importance of high resolution typing and epitope-based antibody analysis.}, author={Amy B . Hahn and V Bravo-Egana and J L Jackstadt and David Conti and Ren{\'e} J. Duquesnoy}, journal={Transplant immunology}, year={2015}, volume={32 3}, pages={141-3} }