HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma.

@article{Hjalgrim2010HLAAAA,
  title={HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma.},
  author={Henrik Hjalgrim and Klaus Rostgaard and Paul C. D. Johnson and Annette Lake and Lesley A Shield and A. Little and Karin Ekstrom-Smedby and Hans-Olov Adami and Bengt L G Glimelius and Stephen Hamilton-Dutoit and Eleanor A. Kane and Graham Malcolm Taylor and Alex McConnachie and Lars Peter Ryder and Christer Sundstr{\"o}m and Paal Skytt Andersen and Ellen T. Chang and Freda E. Alexander and Mads Melbye and Ruth F. Jarrett},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 14},
  pages={
          6400-5
        }
}
A proportion of classical Hodgkin lymphoma (HL) is believed to be causally related to infection with the ubiquitous lymphotropic EBV. The determining factors for development of EBV-related HL remain poorly understood, but likely involve immunological control of the viral infection. Accordingly, markers of the HLA class I region have been associated with risk of EBV-related HL. To study the host genetic component of EBV-related HL further, we investigated the lymphoma's association with HLA-A*01… CONTINUE READING

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